Endocrine Abstracts

Introduction: Elevated low-density lipoprotein cholesterol (LDL-C) is an important risk factor for atherosclerotic cardiovascular disease (ASCVD). Direct LDL-C measurement is not widely performed. LDL-C is typically estimated using the Friedewald (FLDL), Martin-Hopkins (MLDL) or Sampson (SLDL) equations, which may be inaccurate at high triglycerides (TG) or low LDL-C levels. We aimed to determine if machine learning (ML)-derived LDL-C levels agree better with direct LDL-C than...

Background: Branched-chain amino acids (BCAA) are elevated in morbid obesity and decreases significantly following bariatric surgery. This decrease is associated with the post-surgical improvement in insulin resistance (IR) and may be secondary to the reduction in BCAA flux from proteolysis or an increase in BCAA catabolism. Presently, the underlying mechanism is unclear.Aim: To investigate the changes in BCAA metabolism in morbidly obese individuals fol...